Researchers form Institut Pasteur of Shanghai, CAS and Hualan Biological Bacterin Company revealed their new findings on antibody dynamic changing profile following vaccination with the 2009 A/H1N1 influenza vaccine. This findings suggested that multiple immunizations may be required for people with low seasonal influenza antibody levels.
Influenza A viruses cause epidemics every year and occasionally global pandemics due to their highly variable genome. Vaccine development is, to date, the best way to prevent influenza virus infection. The 2009 A/H1N1 pandemic caused more than 18,000 deaths worldwide and vaccines against the 2009 A/H1N1 influenza virus are useful for preventing infection and controlling the pandemic. A human study reported in this paper demonstrated that sufficient protection could be established as early as 10 days after vaccine administration and people with a stronger pre-existing seasonal influenza antibody response may have a relatively higher potential for developing a stronger humoral immune response after vaccination with the 2009 A/H1N1 pandemic influenza vaccine. This study suggests that to obtain an optimal effect for the 2009 A/H1N1 influenza vaccination, one should consider the recipient’s previous seasonal influenza antibody level. It is a potential indicator for predicting whether a good vaccination effect can be achieved.
This research entitled " Immune Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine" was online published in Plos One On Dec.9, 2010.
This work was supported by grants from the National Ministry of Science and Technology, the National Natural Science Foundation of China, the Technology Commission of Shanghai Municipality, the National Science and Technology Major Project, SPHRF, the National 973 key project, the E-institutes of the Shanghai Universities Immunology Division and the Li Kha Shing Foundation.
